Regio- and Enantioselective Iridium-Catalyzed Allylic Alkylation with In Situ Activated P,C-Chelate Complexes

Come together: Successful cooperation of iridium and copper yielded a new catalyst system for allylic alkylation. Branched alkylation products can be obtained rapidly and with high enantioselectivity from simple linear precursors (see scheme; cod=cyclooctadiene).

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 43; no. 35; pp. 4595 - 4597
Main Authors Lipowsky, Gunter, Miller, Nicole, Helmchen, Günter
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 06.09.2004
WILEY‐VCH Verlag
Wiley
Subjects
alkylation
allylic substitution
asymmetric catalysis
Chemistry
Chemistry, Multidisciplinary
iridium
phosphorus amidites
Physical Sciences
Science & Technology
iridium
phosphorus amidites
SUBSTITUTION
AMINATION
LIGANDS
ACETATES
alkylation
allylic substitution
asymmetric catalysis
ETHERIFICATION
Online AccessGet full text

Cover

More Information
Summary:Come together: Successful cooperation of iridium and copper yielded a new catalyst system for allylic alkylation. Branched alkylation products can be obtained rapidly and with high enantioselectivity from simple linear precursors (see scheme; cod=cyclooctadiene).
Bibliography:ark:/67375/WNG-9B1GBNQS-0
This work was supported by the Deutsche Forschungsgemeinschaft (SFB 623) and by the Fonds der Chemischen Industrie. We thank Markus Krauter for competent experimental assistance, Dr. F. Rominger for the X-ray crystal structure, and Degussa AG for iridium salts.
ArticleID:ANIE200460016
istex:4632E838B1D5331FB5D34A36B217DFA258F40EF0
This work was supported by the Deutsche Forschungsgemeinschaft (SFB 623) and by the Fonds der Chemischen Industrie. We thank Markus Krauter for competent experimental assistance, Dr. F. Rominger for the X‐ray crystal structure, and Degussa AG for iridium salts.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460016