D-penicillamine in the treatment of rheumatoid arthritis

Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 m...

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Bibliographic Details
Published inArthritis and rheumatism Vol. 20; no. 2; p. 666
Main Authors Tsang, I K, Patterson, C A, Stein, H B, Robinson, H S, Ford, D K
Format Journal Article
LanguageEnglish
Published United States 01.03.1977
Subjects
Aged
Arthritis, Rheumatoid - drug therapy
Drug Tolerance
Female
Humans
Male
Middle Aged
Penicillamine - adverse effects
Penicillamine - therapeutic use
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Summary:Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patients because of toxic side effects.
ISSN:0004-3591
DOI:10.1002/art.1780200205