Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013-2018

Osteoarthritis (OA) is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA. Weighted multivariable logistic regression model, trend test, restricted cubic spline, and stratified an...

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Bibliographic Details
Published inJournal of occupational and environmental medicine Vol. 66; no. 8; p. e333
Main Authors Li, Lijun, Cao, Jiangang, Li, Lin, Wu, Guang, Xiao, Junhui
Format Journal Article
LanguageEnglish
Published United States 01.08.2024
Subjects
Adult
Aged
Cadmium - blood
Cross-Sectional Studies
Environmental Exposure - adverse effects
Female
Humans
Logistic Models
Male
Middle Aged
Nutrition Surveys
Osteoarthritis - blood
Osteoarthritis - epidemiology
United States - epidemiology
United States
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Summary:Osteoarthritis (OA) is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA. Weighted multivariable logistic regression model, trend test, restricted cubic spline, and stratified analysis were used to study the association between BCd and OA. In the two regression models of weighted multivariable logistic regression analysis, the correlation between BCd and OA was positive. Compared with the lowest quartile of BCd exposure, the highest quartile had a 2.03-fold (95% confidence interval, 1.67 to 2.47), displaying a dose-response relationship (P for trend <0.00001). The restrictive cubic spline shows a positive linear relationship between BCd and OA. There was a positive linear relationship between BCd and OA and a dose-response relationship.
ISSN:1536-5948
DOI:10.1097/JOM.0000000000003135