Recent progress in enantiomeric separation by capillary electrochromatography
Recent progress in enantiomeric separations by capillary electrochromatography (CEC) is reviewed. The development of simple and robust CEC column technologies plays an important role for popularization of CEC. During the last several years, various approaches for the preparation of enantioselective...
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Published in | Electrophoresis Vol. 23; no. 22-23; pp. 4005 - 4021 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.11.2002
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Recent progress in enantiomeric separations by capillary electrochromatography (CEC) is reviewed. The development of simple and robust CEC column technologies plays an important role for popularization of CEC. During the last several years, various approaches for the preparation of enantioselective columns have been reported. Currently, the monolithic column technology (continuous beds) represents the most advanced approach for the preparation of CEC columns. The development of new chiral stationary phase used for CEC is another important issue in this field. Fundamental investigations on electrochromatographic behaviors of various CSPs are necessary in order to understand the separation mechanism and thus improve the separation performance. Some chiral stationary phases performed better under nonaqueous CEC conditions than reversed‐phase conditions. Coupling CEC with mass spectrometry (MS) provides a powerful tool for enantiomeric separation. Finally, some applications of enantiomeric separation by CEC are summarized. |
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Bibliography: | ark:/67375/WNG-NDN8PC0X-7 ArticleID:ELPS200290015 istex:ED22EEA40BCA8BB214081F0B7B3E9532384493B3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0173-0835 1522-2683 |
DOI: | 10.1002/elps.200290015 |