The Exclusivity of Multivalency in Dynamic Covalent Processes

Less is more: It is much less efficient to synthesize both components of a multivalent recognition site separately than it is to use one multivalent component to act as a template for the catalytically orchestrated construction of the other component, as demonstrated by the formation of the mechanic...

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Published inAngewandte Chemie (International ed.) Vol. 43; no. 25; pp. 3273 - 3278
Main Authors Badjić, Jovica D., Cantrill, Stuart J., Grubbs, Robert H., Guidry, Erin N., Orenes, Raul, Stoddart, J. Fraser
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 21.06.2004
WILEY‐VCH Verlag
Wiley
Subjects
Catalysis
Chemistry
Chemistry, Multidisciplinary
metathesis
Models, Chemical
Models, Molecular
molecular recognition
Molecular Structure
Molecular Weight
NMR spectroscopy
Organometallic Compounds - chemistry
Physical Sciences
Polymers - chemical synthesis
Science & Technology
Stereoisomerism
supramolecular chemistry
OLEFIN METATHESIS CATALYSTS
COMBINATORIAL LIBRARIES
DENDRIMERS
metathesis
RING-CLOSING METATHESIS
CROWN-ETHER COMPLEXES
THERMODYNAMIC CONTROL
LIGANDS
AFFINITY
molecular recognition
COOPERATIVITY
NMR spectroscopy
supramolecular chemistry
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Summary:Less is more: It is much less efficient to synthesize both components of a multivalent recognition site separately than it is to use one multivalent component to act as a template for the catalytically orchestrated construction of the other component, as demonstrated by the formation of the mechanically interlocked, triply threaded molecular bundle shown. The situation is reminiscent of nature.
Bibliography:istex:56A0FE813B65531D23D4AAB914857C72F602E805
ark:/67375/WNG-R0JWQJCW-0
ArticleID:ANIE200453963
We thank the National Science Foundation (CHE 0317170) for funding this research which is also supported in part by equipment grants (CHE 9974928 and CHE 0092036) from the National Science Foundation. We also thank the Office of Naval Research for support through its MURI program.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200453963