Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

Right on target: An in vivo tumor‐targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanopartic...

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Published inAngewandte Chemie (International ed.) Vol. 51; no. 47; pp. 11836 - 11840
Main Authors Koo, Heebeom, Lee, Sangmin, Na, Jin Hee, Kim, Sun Hwa, Hahn, Sei Kwang, Choi, Kuiwon, Kwon, Ick Chan, Jeong, Seo Young, Kim, Kwangmeyung
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 19.11.2012
WILEY‐VCH Verlag
Subjects
Animals
Azides - administration & dosage
Azides - chemistry
Azides - metabolism
Cell Line, Tumor
click chemistry
Click Chemistry - methods
Copper - chemistry
drug delivery
Drug Delivery Systems - methods
Hexosamines - administration & dosage
Hexosamines - chemistry
Hexosamines - metabolism
Humans
Liposomes - administration & dosage
Liposomes - chemistry
Lung Neoplasms - drug therapy
Lung Neoplasms - metabolism
metabolic glycoengineering
Mice
nanoparticle
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Polysaccharides - chemistry
Polysaccharides - metabolism
Sialic Acids - chemistry
Sialic Acids - metabolism
tumor targeting
Xenograft Model Antitumor Assays
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Summary:Right on target: An in vivo tumor‐targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper‐free click reaction.
Bibliography:This study was funded by the Global Research Laboratory (GRL) Project, the Fusion Technology Project (2009-0081876), and the Intramural Research Program (Theragnosis) of KIST.
ark:/67375/WNG-8KNB81S2-X
Global Research Laboratory (GRL) Project
Intramural Research Program (Theragnosis) of KIST
Fusion Technology Project - No. 2009-0081876
ArticleID:ANIE201206703
istex:45A78FB1F05278D62AEF44E8B4B3062210DEC003
This study was funded by the Global Research Laboratory (GRL) Project, the Fusion Technology Project (2009‐0081876), and the Intramural Research Program (Theragnosis) of KIST.
These authors contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206703