Comparison of HPV detection in parallel biopsies and cervical scrapes by PCR

PCR was used to detect HPV DNA in cervical scrapes of 23 women with cervical cancer. Compared with PCR-assisted HPV DNA detection in parallel biopsies, the sensitivity was 81% and the specificity 100%. We conclude that cervical scrapes can be used for detection of HPV DNA in women with cervical canc...

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Bibliographic Details
Published inAPMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 100; no. 8; p. 752
Main Authors Ask, E, Jenkins, A, Kaern, J, Trope, C, Kristiansen, B E
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1992
Subjects
Base Sequence
Biopsy
Cervix Uteri - microbiology
DNA, Viral - analysis
Female
Humans
Molecular Sequence Data
Papillomaviridae - isolation & purification
Polymerase Chain Reaction
Sensitivity and Specificity
Specimen Handling
Tumor Virus Infections - diagnosis
Uterine Cervical Neoplasms - microbiology
Vaginal Smears - methods
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Summary:PCR was used to detect HPV DNA in cervical scrapes of 23 women with cervical cancer. Compared with PCR-assisted HPV DNA detection in parallel biopsies, the sensitivity was 81% and the specificity 100%. We conclude that cervical scrapes can be used for detection of HPV DNA in women with cervical cancer.
ISSN:0903-4641
DOI:10.1111/j.1699-0463.1992.tb03995.x