Weakly Oriented Liquid-Crystal NMR Solvents as a General Tool to Determine Relative Configurations

A new NMR method to determine the relative configuration of asymmetric centres is presented. It proceeds through the use of a weakly ordered solvent and the measurement of orientational order parameters. The method is illustrated by using dihydropyridone derivatives for which the orientations and th...

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Bibliographic Details
Published inChemistry : a European journal Vol. 9; no. 18; pp. 4536 - 4539
Main Authors Aroulanda, Christie, Boucard, Valérie, Guibé, François, Courtieu, Jacques, Merlet, Denis
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 22.09.2003
WILEY‐VCH Verlag
Subjects
configuration determination
diastereomers
dipolar couplings
liquid crystals
NMR spectroscopy
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Summary:A new NMR method to determine the relative configuration of asymmetric centres is presented. It proceeds through the use of a weakly ordered solvent and the measurement of orientational order parameters. The method is illustrated by using dihydropyridone derivatives for which the orientations and the relative configurations of the asymmetric carbon atoms are determined unambiguously. The determination of relative configurations of asymmetric centres is an important challenge in chemistry. A new NMR method to determine the relative configuration of asymmetric centres is presented. It proceeds through the use of a weakly ordered solvent and the measurement of orientational order parameters. This method is illustrated for dihydropyridone derivatives (shown here).
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ArticleID:CHEM200204701
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200204701