Effects of sodium restriction on cardiac 3,4-dihydroxyphenylethylene glycol and catecholamine levels in rats

1. The effects of low or high sodium intake for 4 weeks on cardiac catecholamines and 3,4-dihydroxyphenylethylene glycol (DHPG) levels were studied in adult female Wistar rats. 2. Rats receiving the low sodium diet had significantly higher plasma renin activity than rats receiving the high sodium di...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 16; no. 8; p. 671
Main Authors Howes, L G, Hodsman, G P
Format Journal Article
LanguageEnglish
Published Australia 01.08.1989
Subjects
Animals
Catecholamines - metabolism
Diet, Sodium-Restricted
Dopamine - metabolism
Epinephrine - metabolism
Female
Glycols - metabolism
Heart - drug effects
Methoxyhydroxyphenylglycol - metabolism
Myocardium - metabolism
Norepinephrine - metabolism
Organ Size
Radioimmunoassay
Rats
Rats, Inbred Strains
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Summary:1. The effects of low or high sodium intake for 4 weeks on cardiac catecholamines and 3,4-dihydroxyphenylethylene glycol (DHPG) levels were studied in adult female Wistar rats. 2. Rats receiving the low sodium diet had significantly higher plasma renin activity than rats receiving the high sodium diet. 3. Dopamine concentrations in both the right and left ventricle were significantly higher in the low salt compared with the high salt rats, but noradrenaline, adrenaline and DHPG levels did not differ significantly between the two groups. 4. These data do not support previous reports that sodium restriction reduces cardiac noradrenaline release, but suggest that alterations in sodium intake may influence cardiac noradrenaline metabolism.
ISSN:0305-1870
DOI:10.1111/j.1440-1681.1989.tb01619.x