Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle

1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) or ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-2...

Full description

Saved in:
Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 19; no. 6; p. 411
Main Authors Gwee, M C, Cheah, L S
Format Journal Article
LanguageEnglish
Published Australia 01.06.1992
Subjects
4-Aminopyridine - pharmacology
Animals
Depression, Chemical
Electric Stimulation
In Vitro Techniques
Male
Muscle Contraction - drug effects
Muscles - drug effects
Muscles - innervation
Norepinephrine - pharmacology
Ranitidine - pharmacology
Rats
Rats, Inbred Strains
Sympathetic Nervous System - drug effects
Synaptic Transmission - drug effects
Online AccessGet more information

Cover

More Information
Summary:1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) or ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-25 V, 10 Hz for 10 s, 1 ms pulse width) every 2 min, but also potentiated the contractile response to exogenous noradrenaline (5 mumol/L). The inhibited motor responses recovered rapidly and completely after washing out ranitidine. 3. 4-Aminopyridine (100 mumol/L) effectively reversed the partially inhibited (55% or greater) motor responses. 4. The results strongly suggest that ranitidine can inhibit adrenergic transmission in the anococcygeus muscle by a prejunctional mechanism with, presumably, consequent development of supersensitivity of the effector cells to noradrenaline.
ISSN:0305-1870
DOI:10.1111/j.1440-1681.1992.tb00483.x