Paroxetine treatment of delusional disorder, somatic type

• Published in: Human psychopharmacology Vol. 19; no. 5; pp. 351 - 352
• Main Authors: Hayashi, Hiroshi, Oshino, Shingo, Ishikawa, Junichi, Kawakatsu, Shinobu, Otani, Koichi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2004
• Subjects: Aged; Antidepressive Agents, Second-Generation - administration & dosage; Antidepressive Agents, Second-Generation - therapeutic use; delusional disorder somatic type; Female; Humans; Parietal Lobe - diagnostic imaging; paroxetine; Paroxetine - administration & dosage; Paroxetine - therapeutic use; Schizophrenia, Paranoid - diagnostic imaging; Schizophrenia, Paranoid - drug therapy; serotonin; SPECT; Temporal Lobe - diagnostic imaging; Tomography, Emission-Computed, Single-Photon
• ISSN: 0885-6222; 1099-1077
• DOI: 10.1002/hup.590

A 77‐year‐old female showed delusion of infestation in the oral cavity. She was treated by paroxetine 20 mg/day, and the hypochondriacal delusion disappeared after 8 weeks. Hypoperfusion in the left temporal and parietal lobes which was observed when she had the delusion was normalized after resolution of the delusion. This report suggests that paroxetine may be effective for delusional disorder, somatic type. It also supports the previous views that this disorder is associated with serotonergic dysfunction and hypoperfusion in the temporal and parietal lobes. Copyright © 2004 John Wiley & Sons, Ltd.