Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in a herbal product

In our survey of designer drugs in the Japanese market, a cannabimimetic indole was identified as a new active compound in a herbal product. The structure of this compound was elucidated by liquid chromatography–photodiode array–mass spectrometry (LC–PDA–MS), gas chromatography–mass spectrometry (GC...

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Bibliographic Details
Published inForensic toxicology Vol. 31; no. 1; pp. 145 - 150
Main Authors Takahashi, Kazunaga, Uchiyama, Nahoko, Fukiwake, Tomohide, Hasegawa, Takashi, Saijou, Masaaki, Motoki, Yuji, Kikura-Hanajiri, Ruri, Goda, Yukihiro
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.01.2013
Subjects
Forensic Medicine
Forensic Science
Medical Law
Medicinal Chemistry
Medicine
Medicine & Public Health
Pharmacology/Toxicology
Short Communication
indol-3-yl)methanone
4-Ethyl-1-naphthalenyl)(2-methyl-1-pentyl-1
Synthetic cannabinoid
Drug of abuse
JWH-213
Designer drug
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Summary:In our survey of designer drugs in the Japanese market, a cannabimimetic indole was identified as a new active compound in a herbal product. The structure of this compound was elucidated by liquid chromatography–photodiode array–mass spectrometry (LC–PDA–MS), gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance (NMR) analyses. The compound was finally identified as (4-ethyl-1-naphthalenyl)(2-methyl-1-pentyl-1 H -indol-3-yl)methanone (JWH-213), an indole-based cannabinoid receptor ligand. To our knowledge, this is the first finding of JWH-213 as a designer drug in a herbal product. The quantitative LC–PDA analysis showed that the JWH-213 content in the product was 252 mg/pack.
ISSN:1860-8965
1860-8973
DOI:10.1007/s11419-012-0161-6