Self-heating evaluation of superparamagnetic MnFe2O4 nanoparticles for magnetic fluid hyperthermia application towards cancer treatment

• Published in: Ceramics international Vol. 46; no. 16; pp. 25576 - 25583
• Main Authors: Patade, Supriya R., Andhare, Deepali D., Somvanshi, Sandeep B., Jadhav, Swapnil A., Khedkar, Mangesh V., Jadhav, K.M.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2020
• Subjects: FC-ZFC; Hyperthermia; Induction heating; Manganese ferrite; SAR; VSM; Manganese ferrite; VSM; SAR; Hyperthermia; FC-ZFC; Induction heating
• ISSN: 0272-8842; 1873-3956
• DOI: 10.1016/j.ceramint.2020.07.029

In the vision of hyperthermia application, high quality superparamagnetic MnFe2O4 nanoparticles (NPs) were synthesized via low cost and environment-friendly co-precipitation method. Thermogravimetric and differential thermal analysis studies confirmed the ferritization temperature at 900 °C. The formation of crystals with a single-phase cubic spinel structure with the Fd3m space group has been confirmed by XRD analysis. SEM-EDX result reveals that the spherical nature of grains with some agglomeration and elemental analysis helps to calculate the atomic percentage of each detected element. An average particle size (~25 nm) was determined by TEM analysis. VSM analysis shows that saturation magnetization (Ms) increases with decreasing temperature in the range 54.18–59.67emu/g at room temperature (300K) to low temperature (5K), respectively, which displays temperature change affects the saturation magnetization and coercivity. FC-ZFC measurements indicated a blocking temperature of NPs around 97.17K. The induction heating study was performed on MnFe2O4 magnetic NPs at 4 kA/m AC magnetic field amplitude and 280 kHz frequency for application in magnetic hyperthermia. The result demonstrates that the heating ability of MnFe2O4 magnetic NPs can be achieved hyperthermia temperature (42 °C) at small content of 0.4 g/mL within 260sec-time duration, which confirms that the prepared material can be used as a heating agent in magnetic hyperthermic treatment. The specific absorption rate (SAR) was found at 217.62 W/g, the obtained result is superior to the previous reports. The obtained results show that the newly synthesized superparamagnetic NPs can act as a promising candidate for hyperthermia therapy due to its high heat-generating capability at lower concentrations with less time period. [Display omitted]