Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics

Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable st...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 9; no. 35; pp. 71 - 7116
Main Authors Shen, Ke-Han, Lu, Cheng-Hsun, Kuo, Chih-Yu, Li, Bo-Yan, Yeh, Yi-Cheun
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 15.09.2021
Subjects
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biomaterials
Biomedical materials
External stimuli
Fluorescence
Hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - therapeutic use
Infrared Rays
Materials Testing
Nanocomposites
Nanocomposites - chemistry
Nanocomposites - therapeutic use
Nanomaterials
Nanoparticles
Nanotechnology
Near infrared radiation
Remote control
Stability
Transducers
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Summary:Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects. This review article highlights recent research progress on the NIR-responsive nanocomposite hydrogels, focusing on their preparation, properties, applications and future prospectus.
Bibliography:Yi-Cheun Yeh is an Assistant Professor in the Institute of Polymer Science and Engineering at National Taiwan University. She received her BS and MS in Chemistry from National Taiwan Normal University. She pursued her PhD in Chemistry at the University of Massachusetts at Amherst under the guidance of Prof. Vincent Rotello. Upon graduation, she moved to Philadelphia to perform her postdoctoral studies in the polymeric biomaterials laboratory of Prof. Jason Burdick. Presently, her laboratory focuses on engineering the interface between materials and biology, and spans the areas of nanoparticles, biomaterials, and biofabrication.
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ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb00980j