Serum uric acid is associated with cardiac diastolic dysfunction among women with preserved ejection fraction

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 309; no. 5; pp. H986 - H994
• Main Authors: Nogi, Shinpei, Fujita, Shu-Ichi, Okamoto, Yusuke, Kizawa, Shun, Morita, Hideaki, Ito, Takahide, Sakane, Kazushi, Sohmiya, Koichi, Hoshiga, Masaaki, Ishizaka, Nobukazu
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2015
• Subjects: Aged; Aged, 80 and over; Biochemistry; Biomarkers - blood; Cardiology; Diastole; Female; Gender differences; Heart failure; Heart Failure - blood; Heart Failure - physiopathology; Humans; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - physiopathology; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Peptides; Physiology; Regression analysis; Sex Factors; Stroke Volume; Uric Acid - blood; preserved ejection fraction; diastolic dysfunction; sex difference; uric acid
• ISSN: 0363-6135; 1522-1539
• DOI: 10.1152/ajpheart.00402.2015

Serum uric acid (SUA) is associated with the severity and prognosis of systolic heart failure. We investigated the potential association between SUA and cardiac diastolic dysfunction among total of 744 cardiac patients (202 women and 542 men) who had preserved left ventricular ejection fraction. Presence of diastolic dysfunction was assessed by echocardiographic data, plasma B-type natriuretic peptide concentration, and left ventricular hypertrophy. Univariate analysis showed that the prevalence of diastolic dysfunction increased with increasing SUA value in women, but not in men. When sex-nonspecific SUA quartiles were used, multivariate logistic regression analysis, among female patients who were not taking uric acid lowering medication, showed that the third (SUA, 5.7-6.4 mg) and the fourth (SUA, ≥6.5 mg/dl) SUA quartiles were associated with diastolic dysfunction with an odds ratio of 3.25 (P < 0.05) and 8.06 (P < 0.001), respectively, when compared with the first SUA quartile (≤4.7 mg/dl). When sex-specific SUA quartiles were used among these population, multivariate logistic regression analysis showed that the fourth SUA quartile (≥5.7 mg/dl) was associated with diastolic dysfunction with an odds ratio of 5.34 (P < 0.05) when compared with the first SUA quartile (≤4.1 mg/dl). By contrast, the relationship between SUA and diastolic dysfunction was not significant in men, irrespective of which of the sex-nonspecific or sex-specific SUA quartiles were used. These data indicated that among cardiac patients with preserved ejection fraction, SUA was significantly associated with diastolic dysfunction in women but not in men.