Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008

• Published in: Archives of pharmacal research Vol. 35; no. 8; pp. 1387 - 1392
• Main Authors: Wang, Hui, Lu, Zhenyu, Qu, Hai-Jun, Liu, Peipei, Miao, Chengdu, Zhu, Tonghan, Li, Jing, Hong, Kui, Zhu, Weiming
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01.08.2012; 대한약학회
• Subjects: Aflatoxins - administration & dosage; Aflatoxins - isolation & purification; Aflatoxins - pharmacology; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aspergillus flavus - chemistry; Aspergillus flavus - isolation & purification; Bacillus subtilis - drug effects; Cell Line, Tumor; Enterobacter aerogenes - drug effects; Escherichia coli - drug effects; Hibiscus - microbiology; Humans; Inhibitory Concentration 50; K562 Cells; Medicine; Microbial Sensitivity Tests; Pharmacology/Toxicology; Pharmacy; 약학; Mangrove plant; Antibacterial activity; Cytotoxicity; Aflatoxin
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-012-0808-1

A new aflatoxin, aflatoxin B 2b ( 1 ), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes , with MIC values of 22.5, 1.7 and 1.1 M, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC 50 values of 8.1, 2.0 and 4.2 M, respectively. The results showed that hydration and hydrogenation of 8 -double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.