Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondr...

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Bibliographic Details
Published inTrends in immunology Vol. 42; no. 12; pp. 1054 - 1056
Main Author Morel, Laurence
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2021
Elsevier Limited
Subjects
Chronic conditions
Erythrocytes
Glycolysis
Humans
Interferon
Interferon Inducers - metabolism
Interferon Type I - metabolism
Lupus
Lupus Erythematosus, Systemic - metabolism
Macrophages
Mitochondria
Mitochondrial DNA
Oxidative phosphorylation
Pathogenesis
Phosphorylation
Retention
Systemic lupus erythematosus
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Summary:Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2021.10.010