Stimuli-responsive peptide hydrogels for biomedical applications

Stimuli-responsive hydrogels can respond to external stimuli with a change in the network structure and thus have potential application in drug release, intelligent sensing, and scaffold construction. Peptides possess robust supramolecular self-assembly ability, enabling spontaneous formation of nan...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 12; no. 7; pp. 1748 - 1774
Main Authors Zhou, Haoran, Zhu, Yanhua, Yang, Bingbing, Huo, Yehong, Yin, Yuanyuan, Jiang, Xuemei, Ji, Wei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 14.02.2024
Subjects
Biomedical materials
Biosensors
Cell culture
Design
Drug delivery
External stimuli
Hydrogels
Peptides
Self-assembly
Stimuli
Tissue engineering
Wound healing
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Summary:Stimuli-responsive hydrogels can respond to external stimuli with a change in the network structure and thus have potential application in drug release, intelligent sensing, and scaffold construction. Peptides possess robust supramolecular self-assembly ability, enabling spontaneous formation of nanostructures through supramolecular interactions and subsequently hydrogels. Therefore, peptide-based stimuli-responsive hydrogels have been widely explored as smart soft materials for biomedical applications in the last decade. Herein, we present a review article on design strategies and research progress of peptide hydrogels as stimuli-responsive materials in the field of biomedicine. The latest design and development of peptide hydrogels with responsive behaviors to stimuli are first presented. The following part provides a systematic overview of the functions and applications of stimuli-responsive peptide hydrogels in tissue engineering, drug delivery, wound healing, antimicrobial treatment, 3D cell culture, biosensors, etc. Finally, the remaining challenges and future prospects of stimuli-responsive peptide hydrogels are proposed. It is believed that this review will contribute to the rational design and development of stimuli-responsive peptide hydrogels toward biomedical applications. This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications.
Bibliography:Xuemei Jiang is an associate professor at the Bioengineering College of Chongqing University. She obtained her PhD degree in biomedical engineering from Chongqing University (co-trained with the University of Copenhagen) in 2009, and then she joined the Bioengineering College of Chongqing University. Her main research interests include the analysis and characterization of biomaterials.
Wei Ji is a professor at the College of Bioengineering, Chongqing University. He obtained his PhD degree in materials science and engineering from Shanghai Jiao Tong University in 2016, and then worked as a postdoc at Okinawa Institute of Science and Technology and Tel Aviv University. His research interests include peptide self-assembly, supramolecular hydrogels, piezoelectric biomaterials, and bio-inspired smart materials.
Haoran Zhou received his bachelor's degree in agriculture from Sichuan Agricultural University, China, in 2023. In September 2023, he was admitted to pursue a master's degree in biomedical engineering at Chongqing University. His research focuses on bio-inspired self-assembling biomaterials and piezoelectric biomaterials.
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ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d3tb02610h