Hybrid nanomaterial composed of chitosan, curcumin, ZnO and TiO2 for antibacterial therapies

• Published in: International journal of biological macromolecules Vol. 242; no. Pt 2; p. 124814
• Main Authors: Karthikeyan, Chandrasekaran, Jayaramudu, Tippabattini, Núñez, Dariela, Jara, Nery, Opazo-Capurro, Andres, Varaprasad, Kokkarachedu, Kim, Kyobum, Yallapu, Murali M., Sadiku, Rotimi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2023
• Subjects: Antimicrobial; antimicrobial properties; antineoplastic activity; antioxidant activity; breast neoplasms; Cancer cells; Chitosan; Curcumin; Double precipitation; Escherichia coli; fibroblasts; health services; humans; Hybrid nanomaterials; nanoparticles; Staphylococcus aureus; titanium dioxide; toxicity; Antimicrobial; Double precipitation; Curcumin; Hybrid nanomaterials; Chitosan; Cancer cells
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.124814

Metal nanoparticles have been tremendously utilised, such as; antibacterial and anticancer agents. Although metal nanoparticles exhibits antibacterial and anticancer activity, but the drawback of toxicity on normal cells limits their clinical applications. Therefore, improving the bioactivity of hybrid nanomaterial (HNM) and minimizing toxicity is of paramount importance for biomedical applications. Herein, a facile and simple double precipitation method was used to develop biocompatible and multifunctional HNM from antimicrobial chitosan, curcumin, ZnO and TiO2. In HNM, biomolecules chitosan and curcumin were used to control the toxicity of ZnO and TiO2 and improve their biocidal properties. The cytotxicological properties of the HNM was studied against human breast cancer (MDA-MB-231) and fibroblast (L929) cell lines. The antimicrobial activity of the HNM was examined against Escherichia coli and Staphylococcus aureus bacteria, via the well-diffusion method. In addition, the antioxidant property was evaluated by the radical scavenging method. These findings actively, support the ZTCC HNM potential, as an innovative biocidal agent for applications in the clinical and healthcare sectors. •ZnO-TiO2-Chitosan-Curcumin hybrid nanomaterial was prepared in double precipitation.•Morphology studies reveal the ZTCC HNM has a rod-like structure.•The prepared HNM shows less toxicity towards the living cells (L929 cells).•Nanomaterials have significant cell viability, antioxidant and biocidal properties.