Dietary soybean protein compared with casein retards senescence in the senescence accelerated mouse

• Published in: The Journal of nutrition Vol. 123; no. 11; pp. 1905 - 1912
• Main Authors: Umezawa, M, Hosokawa, M, Kohno, A, Ishikawa, S, Kitagawa, K, Takeda, T
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.11.1993
• Subjects: Aging - drug effects; Aging - pathology; Amyloid - metabolism; ANATOMIA ANIMAL; ANATOMIE ANIMALE; Animals; AVEJENTAMIENTO; Biological and medical sciences; Body Weight - drug effects; CASEINA; CASEINE; Caseins - pharmacology; CRECIMIENTO; CROISSANCE; DIETA; Dietary Proteins - pharmacology; ENVEJECIMIENTO; EXPERIMENTACION; EXPERIMENTATION; Feeding. Feeding behavior; Female; FEMELLE; Fundamental and applied biological sciences. Psychology; GLICOPROTEINAS; Glycine max; GLYCOPROTEINE; HEMBRA; LONGEVIDAD; LONGEVITE; MACHO; MALE; Mice; Mice, Inbred Strains; PROTEINAS VEGETALES; PROTEINE VEGETALE; RATON; REGIME ALIMENTAIRE; SENESCENCE; SEXE; SEXO; SOJA; SOURIS; Survival Rate; Vertebrates: anatomy and physiology, studies on body, several organs or systems; VIEILLISSEMENT; Senescence; Rodentia; Soybean; Feeding; Proteins; Soy protein; Vertebrata; Lifetime; Mammalia; Casein; Diet; Mouse; Amyloid; Age; Comparative study
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/123.11.1905

The effects of replacing dietary casein with soybean protein on mean life span, mean life span of the last one-tenth of a group, grading scores of senescence and deposition of senile amyloid were investigated in senescence accelerated mice (SAM-P/1) compared with a control strain (SAM-R/1). SAM-R/1 mice fed the soybean protein-containing diet had mean life spans of 618 +/- 42 d (males) and 578 +/- 62 d (females), 58% (males) and 44% (females) longer than those of corresponding casein fed mice (P 0.01). Similarly, in SAM-P/1 mean life-spans were 265 +/- 16 d (males) and 307 +/- 23 d (females) in the soybean diet group, 27% (males) and 30% (females) longer than in the casein diet groups (P 0.01). The mean life span of the last one-tenth of each group fed soybean protein was significantly longer than the corresponding group fed casein. In SAM-R/1 mice, pathological studies revealed that severe secondary amyloid deposition amyloid A protein) in the kidneys, spleen, stomach and liver was significantly suppressed, in mates only, by replacing casein with soybean protein (P 0.01). The occurrence of contracted kidneys caused by the infiltration of amyloid A protein was suppressed in SAM-R/1 mice fed the soybean protein-containing diet (P 0.05). The deposition of senile amyloid in SAM-P/1 mice with aging was retarded by replacing casein with soybean protein (P 0.01). These results indicate that dietary protein source is important in modulating the advance of senescence in SAM mice