High performance bio-based hyperbranched polyurethane/carbon dot-silver nanocomposite: a rapid self-expandable stent

• Published in: Biofabrication Vol. 8; no. 4; p. 045013
• Main Authors: Duarah, Rituparna, Singh, Yogendra P, Gupta, Prerak, Mandal, Biman B, Karak, Niranjan
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 27.10.2016
• Subjects: Animals; Aorta - cytology; Aorta - metabolism; Blood Platelets - cytology; Carbon - chemistry; Cell Adhesion - drug effects; Cell Survival - drug effects; Cells, Cultured; cytocompatible; Escherichia coli - drug effects; Hemolysis - drug effects; hyperbranched polyurethane nanocomposite; Metal Nanoparticles - chemistry; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Nanocomposites - chemistry; Nanocomposites - toxicity; Polyurethanes - chemistry; self-expandable stent; Silver - chemistry; smart polymer; Staphylococcus aureus - drug effects; starch; Stents; Swine; Temperature; Tensile Strength
• ISSN: 1758-5090; 1758-5090
• DOI: 10.1088/1758-5090/8/4/045013

Development of a bio-based smart implantable material with multifaceted attributes of high performance, potent biocompatibility and inherent antibacterial property, particularly against drug resistant bacteria, is a challenging task in biomedical domain. Addressing these aspects at the bio-nano interface, we report the in situ fabrication of starch modified hyperbranched polyurethane (HPU) nanocomposites by incorporating different weight percentages of carbon dot-silver nanohybrid during polymerization process. This nanohybrid and its individual nanomaterials (Ag and CD) were prepared by facile hydrothermal approaches and characterized by various instrumental techniques. The structural insight of the nanohybrid, as well as its nanocomposites was evaluated by TEM, XRD, FTIR, EDX and thermal studies. The significant improvement in the performance in terms of tensile strength (1.7 fold), toughness (1.5 fold) and thermal stability (20 °C) of the pristine HPU was observed by the formation of nanocomposite with 5 wt.% of nanohybrid. They also showed notable shape recovery (99.6%) and nearly complete self-expansion (>99%) just within 20s at (37 1) °C. Biological assessment established in vitro cytocompatibility of the HPU nanocomposites. The fabricated nanocomposites not only assisted the growth and proliferation of smooth muscle cells and endothelial cells that exhibited reduced platelet adhesion but also displayed in vitro hemocompatibility of mammalian RBCs. Significantly, the antibacterial potency of the nanocomposites against Escherichia coli MTCC 40 and Staphylococcus aureus MTCC 3160 bacterial strains vouched for their application to countercheck bacterial growth, often responsible for biofilm formation. Thus, the present work forwards the nanocomposites as potential tough infection-resistant rapid self-expandable stents for possible endoscopic surgeries.