Immunotherapy for Head and Neck Cancer

The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients...

Full description

Saved in:
Bibliographic Details
Published inOral and maxillofacial surgery clinics of North America Vol. 31; no. 1; p. 85
Main Authors Sim, Felix, Leidner, Rom, Bell, Richard Bryan
Format Journal Article
LanguageEnglish
Published United States 01.02.2019
Subjects
Antibodies, Monoclonal, Humanized - therapeutic use
Antineoplastic Agents, Immunological - therapeutic use
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - therapy
Humans
Immunotherapy - methods
Neoplasm Recurrence, Local - therapy
Nivolumab - therapeutic use
Checkpoint inhibitor
Head and neck cancer
Squamous cell carcinoma
Oncolytic virus
Adoptive T-cell transfer
Immunotherapy
Online AccessGet more information

Cover

More Information
Summary:The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.
ISSN:1558-1365
DOI:10.1016/j.coms.2018.09.002