The complement component C4 in black Americans with type 1 (insulin-dependent) diabetes mellitus

The complement component C4 variants C4A 4, C4B 4 and C4B Q0 were found to be significantly increased in 64 black patients with Type 1 (insulin-dependent) diabetes compared with 169 black control subjects, yielding relative risks of 3.3, 2.9 and 3.4, respectively. The increased frequencies of C4B 4...

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Bibliographic Details
Published inDiabetologia Vol. 26; no. 2; p. 166
Main Authors Budowle, B, Roseman, J M, Go, R C, Barger, B O, Acton, R T
Format Journal Article
LanguageEnglish
Published Germany 01.02.1984
Subjects
Adult
Black or African American
Black People
Complement C4 - genetics
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - genetics
Humans
Phenotype
Risk
United States
White People
United States
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Summary:The complement component C4 variants C4A 4, C4B 4 and C4B Q0 were found to be significantly increased in 64 black patients with Type 1 (insulin-dependent) diabetes compared with 169 black control subjects, yielding relative risks of 3.3, 2.9 and 3.4, respectively. The increased frequencies of C4B 4 and C4B Q0 in black Type 1 diabetic patients are similar to those found in Caucasoid Type 1 diabetic patients. The data suggest that Type 1 diabetes in black Americans may be partially due to admixture of genes from whites.
ISSN:0012-186X
DOI:10.1007/BF00281127