Prediction of renal crystalline size distributions in space using a PBE analytic model. 1. Effect of microgravity-induced biochemical alterations

• Published in: American journal of physiology. Renal physiology Vol. 311; no. 3; pp. F520 - F530
• Main Authors: Kassemi, Mohammad, Thompson, David
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2016
• Subjects: Biochemistry; Calcium Oxalate; Humans; Kidney - pathology; Kidney Calculi - etiology; Kidney Calculi - pathology; Kidney stones; Kidneys; Models, Theoretical; Nephrolithiasis - etiology; Nephrolithiasis - pathology; Predictions; Risk Assessment; Space Flight; Weightlessness; nephrolithiasis; agglomeration; crystal nucleation; crystal growth; weightlessness; gravity

An analytical Population Balance Equation model is developed and used to assess the risk of critical renal stone formation for astronauts during future space missions. The model uses the renal biochemical profile of the subject as input and predicts the steady-state size distribution of the nucleati...