Prediction of renal crystalline size distributions in space using a PBE analytic model. 1. Effect of microgravity-induced biochemical alterations

• Published in: American journal of physiology. Renal physiology Vol. 311; no. 3; pp. F520 - F530
• Main Authors: Kassemi, Mohammad, Thompson, David
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2016
• Subjects: Biochemistry; Calcium Oxalate; Humans; Kidney - pathology; Kidney Calculi - etiology; Kidney Calculi - pathology; Kidney stones; Kidneys; Models, Theoretical; Nephrolithiasis - etiology; Nephrolithiasis - pathology; Predictions; Risk Assessment; Space Flight; Weightlessness; nephrolithiasis; agglomeration; crystal nucleation; crystal growth; weightlessness; gravity
• ISSN: 1931-857X; 1522-1466; 1522-1466
• DOI: 10.1152/ajprenal.00401.2015

An analytical Population Balance Equation model is developed and used to assess the risk of critical renal stone formation for astronauts during future space missions. The model uses the renal biochemical profile of the subject as input and predicts the steady-state size distribution of the nucleating, growing, and agglomerating calcium oxalate crystals during their transit through the kidney. The model is verified through comparison with published results of several crystallization experiments. Numerical results indicate that the model is successful in clearly distinguishing between 1-G normal and 1-G recurrent stone-former subjects based solely on their published 24-h urine biochemical profiles. Numerical case studies further show that the predicted renal calculi size distribution for a microgravity astronaut is closer to that of a recurrent stone former on Earth rather than to a normal subject in 1 G. This interestingly implies that the increase in renal stone risk level in microgravity is relatively more significant for a normal person than a stone former. However, numerical predictions still underscore that the stone-former subject carries by far the highest absolute risk of critical stone formation during space travel.