Teratological evaluation of Juniperus sabina essential oil in mice

Juniperus sabina essential oil was evaluated for its fetotoxic potential on mice. Pregnant dams were injected s.c. (15-45 or 135 mg essential oil/kg body weight) on days 6 to 15 of gestation. They were killed and the uterine contents were examined on day 19 of pregnancy. The fetuses were removed for...

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Bibliographic Details
Published inPlanta medica Vol. 55; no. 2; pp. 144 - 146
Main Authors Pages, N, Fournier, G, Chamorro, G, Salazar, M, Paris, M, Boudene, C
Format Journal Article
LanguageEnglish
Published Germany 01.04.1989
Subjects
abortion
Animals
essential oils
Female
fetotoxic potential
Juniperus sabina
Mice
Oils, Volatile - toxicity
Plant Oils - toxicity
teratogenesis
Teratogens
Trees - analysis
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Summary:Juniperus sabina essential oil was evaluated for its fetotoxic potential on mice. Pregnant dams were injected s.c. (15-45 or 135 mg essential oil/kg body weight) on days 6 to 15 of gestation. They were killed and the uterine contents were examined on day 19 of pregnancy. The fetuses were removed for examination. The dams of the two higher treated groups showed a significant weight loss as compared to controls. An hepatotoxicity was observed among females that resorbed their whole litter, thus indicating a greater susceptibility towards Juniperus sabina essential oil during pregnancy. The essential oil induced, in the three treated groups, an embryotoxicity as manifested by a statistically significant increase in the number of affected litters; but no fetotoxicity.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-961908