Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside

• Published in: Clinical science (1979) Vol. 134; no. 21; pp. 2893 - 2895
• Main Authors: Hunter, Robert W, Dhaun, Neeraj
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 13.11.2020
• Subjects: Cardiovascular System & Vascular Biology; Commentaries; Extracellular Space - metabolism; Humans; Kidney - metabolism; Kidney - pathology; Kidney Diseases - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; RNA - metabolism; Translational Medical Research; microRNA; renal physiology; therapeutics

We have known for just over a decade that functional RNA is shuttled between cells (Nat. Cell Biol. (2007) 9, 654-659). In that short time, there have been countless reports of extracellular RNA (exRNA) and extracellular vesicles (EVs) participating in diverse biological processes in development (De...