Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside

We have known for just over a decade that functional RNA is shuttled between cells (Nat. Cell Biol. (2007) 9, 654-659). In that short time, there have been countless reports of extracellular RNA (exRNA) and extracellular vesicles (EVs) participating in diverse biological processes in development (De...

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Bibliographic Details
Published inClinical science (1979) Vol. 134; no. 21; pp. 2893 - 2895
Main Authors Hunter, Robert W, Dhaun, Neeraj
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 13.11.2020
Subjects
Cardiovascular System & Vascular Biology
Commentaries
Extracellular Space - metabolism
Humans
Kidney - metabolism
Kidney - pathology
Kidney Diseases - metabolism
MicroRNAs - genetics
MicroRNAs - metabolism
RNA - metabolism
Translational Medical Research
microRNA
renal physiology
therapeutics
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Summary:We have known for just over a decade that functional RNA is shuttled between cells (Nat. Cell Biol. (2007) 9, 654-659). In that short time, there have been countless reports of extracellular RNA (exRNA) and extracellular vesicles (EVs) participating in diverse biological processes in development (Dev. Cell (2017) 40, 95-103), homoeostasis (Nature (2017) 542, 450-455) and disease (Nature (2017) 546, 498-503). Unsurprisingly - as these disciplines are still in their infancies - most of this work is still in the 'discovery biology' phase. However, exRNA and EVs show promise as disease biomarkers and could be harnessed in novel therapies.
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ISSN:0143-5221
1470-8736
DOI:10.1042/CS20201092