The dual role of SOX17 in the occurrence and development of early colorectal cancer

Specifically, SOX17 was found to attenuate the IFNγ signaling pathway within early CRC cells and precancerous cells, consequently diminishing the production of MHC-I protein and CXCL10. [...]SOX17 demonstrated the capacity to drive the differentiation of intestinal stem cells into LGR5− intestinal s...

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Bibliographic Details
Published inMolecular biomedicine Vol. 5; no. 1; pp. 38 - 4
Main Authors Su, Xinming, Shentu, Jianqiao, Chen, Ruixiu, Duan, Shiwei
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 16.09.2024
Springer Nature B.V
Springer
Subjects
Biomarkers
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cell cycle
Colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
CRISPR
Editing
Gene Expression Regulation, Neoplastic
Humans
Immune evasion
Immune system
Immunotherapy
Molecular Medicine
Mutation
Research Highlight
SOX17
SOXF Transcription Factors - genetics
SOXF Transcription Factors - metabolism
Stem cells
Teams
Therapeutic targets
Tumor initiation
Tumors
Tumor initiation
Immune evasion
SOX17
Colorectal cancer
Therapeutic targets
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Summary:Specifically, SOX17 was found to attenuate the IFNγ signaling pathway within early CRC cells and precancerous cells, consequently diminishing the production of MHC-I protein and CXCL10. [...]SOX17 demonstrated the capacity to drive the differentiation of intestinal stem cells into LGR5− intestinal stem cells characterized by low MHC-I expression. [...]levels of MHC-I and CXCL10 are diminished, thereby hindering the mechanism of CD8+ T cell-mediated tumor elimination. Easwaran's team focused on female mice due to the influence of X chromosome genes and sex hormones on cell growth, division, and gene expression, which significantly impacted editing efficiency and outcomes. [...]meticulous exploration and validation of these intricate factors are imperative for accurately elucidating the function of SOX17 and its underlying mechanisms across varying conditions. [...]despite both studies using CRISPR lentiviral vectors for mouse organoid editing, discrepancies arise from the utilization of distinct guide RNA sequences.
Bibliography:ObjectType-Article-1
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ISSN:2662-8651
2662-8651
DOI:10.1186/s43556-024-00201-2