Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

• Published in: Biotechnology and bioprocess engineering Vol. 24; no. 1; pp. 48 - 64
• Main Authors: Rhie, Mi Na, Kim, Hee Taek, Jo, Seo Young, Chu, Luan Luong, Baritugo, Kei-Anne, Baylon, Mary Grace, Lee, Jinwon, Na, Jeong-Geol, Kim, Lyul Ho, Kim, Tae Wan, Park, Chulhwan, Hong, Soon Ho, Joo, Jeong Chan, Park, Si Jae
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.02.2019; Springer Nature B.V; 한국생물공학회
• Subjects: Amino acids; Biodiesel fuels; Bioengineering; Biomass; Biorefineries; Biotechnology; Carbon; Chemical engineering; Chemistry; Chemistry and Materials Science; Dehydrogenases; Dependence; Diesel fuels; E coli; Enzymes; Factories; Fermentation; Genomes; Glucose; Glycerol; Industrial and Production Engineering; Kinases; Klebsiella; Klebsiella pneumoniae; Lignocellulose; Metabolic engineering; Metabolism; Microorganisms; Nucleotide sequence; Oils & fats; Organic chemistry; Petroleum; Production increases; Review Paper; Substrates; Sugar; Yeast; 생물공학; biorefinery; carbon utilization; biomass; microbial cell factory; metabolic engineering
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-018-0346-x

The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli , the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.