Transforming recalcitrant wastes into biodiesel by oleaginous yeast: An insight into the metabolic pathways and multi-omics landscape

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 474; p. 145625
• Main Authors: Sartaj, Km, Prasad, Ramasare, Matsakas, Leonidas, Patel, Alok
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.10.2023
• Subjects: Biochemical Process Engineering; Biodiesel; Biokemisk processteknik; Metabolic pathway; Oleaginous yeast; Omics technique; Recalcitrant waste; Omics technique; Metabolic pathway; Recalcitrant waste; Oleaginous yeast; Biodiesel
• ISSN: 1385-8947; 1873-3212; 1873-3212
• DOI: 10.1016/j.cej.2023.145625

[Display omitted] •Oleaginous yeast offers sustainable solution to energy scarcity, waste mitigation.•Metabolic pathways coupling waste degradation and lipid synthesis are portrayed.•Biodiesel derived from oleaginous yeast grown in waste, meets fuel standards.•Omics approaches are robust tool to advance the waste bioconversion into lipids. The escalating challenge of waste disposal and the potential threat to global energy supply have sparked renewed interest in repurposing waste materials for the production of sustainable and renewable fuels. In line with this objective, there has been a growing focus on biodiesel production from oleaginous yeast through the valorization of waste. While numerous reports have been published on this subject, only a limited number of studies provide a comprehensive overview of recent advancements. To address this gap and the economic viability challenges associated with yeast-derived biodiesel production, the present review aims to highlight the opportunities offered by various recalcitrant wastes as a renewable feedstock for oleaginous yeast cultivation. The review also delves into extensive knowledge about the metabolic pathways that facilitate the conversion of different recalcitrant wastes into single-cell oil (SCO), which has not been extensively covered in a single platform before. Moreover, the most promising species of oleaginous yeast are described, taking into consideration economic aspects and the sustainability of the overall process. Furthermore, the review emphasizes the application of omics techniques to advance waste bioconversion into lipids for the purpose of commercialization. In summary, this study contributes to expanding our current understanding of the topic and facilitates the future upscaling and commercialization of biodiesel derived from oleaginous yeasts.