Spatial distribution of back scattering in the nuclear area of the non-cataractous human lens

• Published in: Eye (London) Vol. 8; no. 5; pp. 524 - 529
• Main Authors: QIAN, W, SÖDERBERG, P, LINDSTRÖM, B, CHEN, E, MAGNIUS, K, PHILIPSON, B
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.01.1994
• Subjects: Aged; Analysis of Variance; Biological and medical sciences; Female; Humans; Investigative techniques of ocular function and vision; Investigative techniques, diagnostic techniques (general aspects); Lens Nucleus, Crystalline - physiology; Light; Male; Mathematics; Medical sciences; Middle Aged; Models, Biological; Photography; Random Allocation; Scattering, Radiation; Sensitivity and Specificity; Human; Photography; Back surface; Slitlamp; Exploration; Lens; Diffusion
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/eye.1994.130

The spatial distribution of back scattering from a vertical cross-section of the nuclear area in non-cataractous human lens was investigated. The cross-section was centred on the pupil. There is no significant difference in average nuclear back scattering between sides. The distribution of back scattering along an axis perpendicular to the anatomical axis can be modelled as a second-order polynomial. It is believed that the increase of back scattering in the central region corresponds to the peak protein concentration in the centre of the nucleus. This information was obtained by imaging back scattering with Scheimpflug photography. The back scattering was measured photometrically in a 3 x 10 matrix of measuring areas within the lens nucleus. Each measuring area was 0.20 x 0.20 mm in size. It is anticipated that the established model will allow detection of nuclear cataract with high sensitivity, especially in early stages.