Samarium vanadate nanospheres integrated carbon nanofiber composite as an efficient electrocatalyst for antituberculosis drug detection in real samples

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Vol. 617; p. 126385
• Main Authors: Nataraj, Nandini, Chen, Shen-Ming
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.05.2021
• Subjects: Antituberculosis drug; Bimetallic composite; Biological samples; Carbon nanofiber; Pharmaceutical sample; Carbon nanofiber; Pharmaceutical sample; Bimetallic composite; Biological samples; Antituberculosis drug
• ISSN: 0927-7757; 1873-4359
• DOI: 10.1016/j.colsurfa.2021.126385

The overall electrochemical detection of isoniazid with SmVO4/CNF/GCE. [Display omitted] •Developing a bimetallic platform integrated with CNF for selective detection of ISZ.•Conformational studies illustrate the well-defined SmVO4 formation via XPS, XRD, RAMAN, FTIR.•DPV and CV techniques used for electrochemical studies.•Limit of detection attained at 0.0059 μM.•Real time studies with biological and pharmaceutical samples. We have explored an electrochemical sensing platform based on samarium vanadate nanosphere embedded carbon nanofiber (SmVO4/CNF) for the determination of antituberculosis drug isoniazid (ISZ). The physicochemical properties were recognized, proving the well-aligned presence of SmVO4/CNF. The samples obtained were tested for electrochemical studies as electrochemical impedance spectroscopy (EIS), determining the lower resistance resulting in higher conductivity with Rct at 53 Ω. Prospective enhancement was observed for SmVO4/CNF/GCE with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) towards isoniazid electrochemical detection. The effective active surface area was calculated to be 0.155 cm−2 for SmVO4/CNF/GCE being two times larger than bare GCE with CV analysis. A lower detection limit of about 0.005 μM and a limit of quantification of about 0.0198 μM were significantly recognized with the linear range of about 0.09−800 μM as obtained by DPV analysis. Coexisting materials with ISZ had no interactions establishing excellent selectivity among interfering molecules. Biological and pharmaceutical samples exposed for real-time studies with an effective recovery range. Thus, collecting all these results will be a useful sensor being fabricated with SmVO4/CNF for synergetic detection of ISZ in real samples.