Glioma-Induced Disruption of Resting-State Functional Connectivity and Amplitude of Low-Frequency Fluctuations in the Salience Network

• Published in: American journal of neuroradiology : AJNR Vol. 42; no. 3; pp. 551 - 558
• Main Authors: Yang, J, Gohel, S, Zhang, Z, Hatzoglou, V, Holodny, A I, Vachha, B A
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01.03.2021
• Subjects: Adult; Brain Mapping - methods; Brain Neoplasms - physiopathology; Female; Functional; Glioma - physiopathology; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Nerve Net - physiopathology
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/AJNR.A6929

Cognitive challenges are prevalent in survivors of glioma, but their neurobiology is incompletely understood. The purpose of this study was to investigate the effect of glioma presence and tumor characteristics on resting-state functional connectivity and amplitude of low-frequency fluctuations of the salience network, a key neural network associated with cognition. Sixty-nine patients with glioma (mean age, 48.74 [SD, 14.32] years) who underwent resting-state fMRI were compared with 31 healthy controls (mean age, 49.68 [SD, 15.54] years). We identified 4 salience network ROIs: left/right dorsal anterior cingulate cortex and left/right anterior insula. Average salience network resting-state functional connectivity and amplitude of low-frequency fluctuations within the 4 salience network ROIs were computed. Patients with gliomas showed decreased overall salience network resting-state functional connectivity ( = .001) and increased amplitude of low-frequency fluctuations in all salience network ROIs ( < .01) except in the left dorsal anterior cingulate cortex. Compared with controls, patients with left-sided gliomas showed increased amplitude of low-frequency fluctuations in the right dorsal anterior cingulate cortex ( = .002 and right anterior insula ( < .001), and patients with right-sided gliomas showed increased amplitude of low-frequency fluctuations in the left anterior insula ( = .002). Anterior tumors were associated with decreased salience network resting-state functional connectivity ( < .001) and increased amplitude of low-frequency fluctuations in the right anterior insula, left anterior insula, and right dorsal anterior cingulate cortex. Patients with high-grade gliomas had decreased salience network resting-state functional connectivity compared with healthy controls ( < .05). The right anterior insula showed increased amplitude of low-frequency fluctuations in patients with grade II and IV gliomas compared with controls ( < .01). By demonstrating decreased resting-state functional connectivity and an increased amplitude of low-frequency fluctuations related to the salience network in patients with glioma, this study adds to our understanding of the neurobiology underpinning observable cognitive deficits in these patients. In addition to more conventional functional connectivity, amplitude of low-frequency fluctuations is a promising functional-imaging biomarker of tumor-induced vascular and neural pathology.