Gallic acid functionalized polylysine for endowing cotton fiber with antibacterial, antioxidant, and drug delivery properties

• Published in: International journal of biological macromolecules Vol. 216; pp. 65 - 74
• Main Authors: Zhang, Wen, Zeng, Qing-Min, Tang, Ren-Cheng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2022
• Subjects: aldehydes; Antibacterial; Antioxidant; antioxidants; aspirin; biomass; Cotton; Drug delivery; Gallic acid; lint cotton; oxidation; Polylysine; public health; schiff bases; Drug delivery; Antibacterial; Gallic acid; Cotton; Polylysine; Antioxidant
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2022.06.186

In recent years, the serious influence of infectious diseases on public health and economy development has raised global awareness of the importance of medical textiles for preventing and curing injuries and diseases. The application of biomass molecules is a feasible and sustainable approach to design multipurpose medical materials. In this work, a novel cotton fiber with antibacterial, antioxidant, and drug delivery properties was prepared using gallic acid functionalized polylysine (GA-PL). GA-PL was synthesized by immobilizing GA onto PL using the carbodiimide coupling method. The content of GA immobilized onto PL was 117.9 mg/g. The as-prepared GA-PL was grafted onto oxidized cotton by means of the Schiff base reaction between the amino groups of GA-PL and the aldehyde groups of oxidized cotton. The content of GA-PL grafted onto cotton fiber was 205.1 mg/g. GA-PL grafted cotton fiber exhibited not only durable antibacterial and antioxidant activities but also good drug loading and releasing properties for acetylsalicylic acid. This work presents a novel, cleaner, and sustainable approach to prepare medical cotton fibers with bioactive and drug delivery properties. [Display omitted] •Polylysine is functionalized with gallic acid by carbodiimide coupling.•Oxidized cotton fiber is grafted with gallic acid functionalized polylysine.•Resulting cotton fiber exhibits durable antibacterial and antioxidant functions.•Resulting cotton fiber exhibits drug delivery property.•Resulting cotton fiber has application prospects in medical textiles.