Effect of Dietary Fat Level on Growth and Lipogenesis in the Colostrum Deprived Neonatal Pig

• Published in: The Journal of nutrition Vol. 107; no. 12; pp. 2100 - 2108
• Main Authors: Wolfe, Ronald G., Maxwell, Charles V., Nelson, Eldon C., Johnson, Ronald R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.1977
• Subjects: Animals; Animals, Newborn; Body Weight; Colostrum; Dietary Fats - administration & dosage; fat utilization; Fatty Acids - metabolism; Female; Lactation; Lipids - biosynthesis; lipogenesis; Male; neonatal pig; Nutrition Disorders - metabolism; Pregnancy; Swine - metabolism; Tissue Distribution; fat utilization; lipogenesis; neonatal pig
• ISSN: 0022-3166
• DOI: 10.1093/jn/107.12.2100

Thirty male neonatal pigs were obtained by cesarean section and randomly allotted from littermate groups to three diets containing 2%, 17%, and 32% fat on a dry matter basis. Butterfat was used to replace glucose in the isoenergetic liquid, semipurified diets. Each pig was placed in a sterile isolator and fed ad libitum five times daily. After 14 days, pigs were weighted, killed, and samples of liver and backfat were obtained. The carcass of each pig was ground and samples obtained for determination of total body fat and protein. An increase in the level of dietary fat resulted in a significant increase in 14 day weight gain and a tendency for improved feed efficiency. These results demonstrate not only that the neonatal pig can utilize semipurified liquid diets high in butterfat content, but also that energy from butterfat appears to be used as efficiently as energy from glucose for growth purposes. Increasing dietary fat level decreased the activity of fatty acid synthetase and citrate cleavage enzyme in adipose tissue and liver, and decreased the activity of malic enzyme in adipose tissue. The specific activities of these three enzymes were higher in adipose tissue than in liver.