Gas and gas-generating nanoplatforms in cancer therapy

Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H 2 ), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitocho...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 9; no. 41; pp. 8541 - 8557
Main Authors Jing, Yuan-Zhe, Li, Shu-Jin, Sun, Zhi-Jun
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 27.10.2021
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Cancer
Cancer therapies
Carbon monoxide
Carbon Monoxide - chemistry
Carbon Monoxide - pharmacology
Controlled release
Gases
Gases - chemistry
Gases - pharmacology
Humans
Hydrogen - chemistry
Hydrogen - pharmacology
Hydrogen sulfide
Hydrogen Sulfide - chemistry
Hydrogen Sulfide - pharmacology
Macrophages
Microenvironments
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Nanoparticles - chemistry
Nanotechnology
Neoplasms - drug therapy
Neoplasms - metabolism
Nitric oxide
Nitric Oxide - chemistry
Nitric Oxide - pharmacology
Phenotypes
Side effects
Therapy
Tumor microenvironment
Tumors
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Abstract Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H 2 ), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, H 2 S and H 2 in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy. Gas-generating nanoplatforms have promising therapeutic potential for cancer treatment.
AbstractList Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H ), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, H S and H in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy.
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H 2 ), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, H 2 S and H 2 in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy. Gas-generating nanoplatforms have promising therapeutic potential for cancer treatment.
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H 2 ), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, H 2 S and H 2 in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy.
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H2), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, H2S and H2 in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy.
Author Jing, Yuan-Zhe
Li, Shu-Jin
Sun, Zhi-Jun
AuthorAffiliation Wuhan University
School and Hospital of Stomatology
Department of Oral Maxillofacial-Head Neck Oncology
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education
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Notes Dr Zhi-Jun Sun received his doctoral degree from Wuhan University in 2006 and was a visiting postdoctoral fellow at the National Institutes of Health (NIH) in Bethesda (2009-2012). He is working as a professor (2013 to present) at Wuhan University. He has published more than 130 peer-reviewed articles, and his research interests include the mechanism of tumor immune evasion and the use of nanomaterials to enhance anti-tumor immunity.
Yuan-Zhe Jing was born in Beijing, China, in 1994. She received her master's degree from Wuhan University in 2021 under the guidance of Prof. Zhi-Jun Sun. Presently her research interest is focused on gas therapy and gas-generating nanoplatforms in cancer therapy.
Shu-Jin Li was born in Jiangsu, China, in 1998. He received his BS degree (2021) in Stomatology from Wuhan University. He is currently a PhD student working under Prof. Zhi-Jun Sun's supervision at Wuhan University. His current research focuses on improving the efficacy of immuno-checkpoint inhibitors in oral cancer.
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Snippet Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H 2 ), nitric oxide (NO), carbon monoxide...
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H ), nitric oxide (NO), carbon monoxide...
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H2), nitric oxide (NO), carbon monoxide...
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SubjectTerms Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Cancer
Cancer therapies
Carbon monoxide
Carbon Monoxide - chemistry
Carbon Monoxide - pharmacology
Controlled release
Gases
Gases - chemistry
Gases - pharmacology
Humans
Hydrogen - chemistry
Hydrogen - pharmacology
Hydrogen sulfide
Hydrogen Sulfide - chemistry
Hydrogen Sulfide - pharmacology
Macrophages
Microenvironments
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Nanoparticles - chemistry
Nanotechnology
Neoplasms - drug therapy
Neoplasms - metabolism
Nitric oxide
Nitric Oxide - chemistry
Nitric Oxide - pharmacology
Phenotypes
Side effects
Therapy
Tumor microenvironment
Tumors
Title Gas and gas-generating nanoplatforms in cancer therapy
URI https://www.ncbi.nlm.nih.gov/pubmed/34608920
https://www.proquest.com/docview/2586467937
https://search.proquest.com/docview/2579376942
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