Anti tumor necrosis factor induced focal myositis

Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain and is diagnosed based on magnetic resonance...

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Bibliographic Details
Published inProceedings of Singapore Healthcare Vol. 31; p. 201010582211477
Main Authors Masnammany, Adrian Mark, Lau, Wendy, Wong, Peter Kee Kee, Manolios, Nicholas
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.12.2022
Sage Publications Ltd
SAGE Publishing
Subjects
Autoimmune diseases
Case reports
Inflammatory bowel disease
Inflammatory diseases
Monoclonal antibodies
Musculoskeletal diseases
Rheumatology
Tumor necrosis factor-TNF
gastroenterology
tumor necrosis factor
immunology
Rheumatology
myositis
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Summary:Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain and is diagnosed based on magnetic resonance imaging (MRI), electromyography (EMG) and muscle histopathology. We report the first case of TNFi-induced focal myositis in the left thigh of a patient with ulcerative colitis on infliximab. A 30-year-old lady presented with left thigh pain with no other systemic manifestation or muscle weakness. The immunology profile showed positivity of antinuclear antibody (ANA), high titre of anti-ds-DNA, and anti-Mi-2 without any features of systemic lupus erythematosus or dermatomyositis. Discontinuation of the TNFi and commencement of glucocorticoids resulted in the resolution of the myositis.
ISSN:2010-1058
2059-2329
DOI:10.1177/20101058221147755