Alterations in Protein and Nucleic Acid Metabolism of Thymocytes Produced by Adrenal Steroids in Vitro

Thymocytes from cortisol-treated rats, incubated in vitro , showed a lower incorporation of radioactive precursors into ribonucleic acid, deoxyribonucleic acid, and protein than did cells from control animals. Thymolytic steroids present in vitro at concentrations of 10 -10 m to 10 -5 m in the thymo...

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Published inThe Journal of biological chemistry Vol. 241; no. 7; pp. 1646 - 1648
Main Authors Makman, M H, Dvorkin, B, White, A
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 10.04.1966
Subjects
Animals
DNA - biosynthesis
Glycine - metabolism
Hydrocortisone - pharmacology
In Vitro Techniques
Leucine - metabolism
Nucleosides - metabolism
Protein Biosynthesis
Rats
RNA - biosynthesis
Thymidine - metabolism
Thymus Gland - cytology
Thymus Gland - metabolism
Uridine - metabolism
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Summary:Thymocytes from cortisol-treated rats, incubated in vitro , showed a lower incorporation of radioactive precursors into ribonucleic acid, deoxyribonucleic acid, and protein than did cells from control animals. Thymolytic steroids present in vitro at concentrations of 10 -10 m to 10 -5 m in the thymocyte suspensions caused similar inhibitions. Good correlation was found between relative potency of the steroids tested in vitro and their reported potency assessed in vivo .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)96761-X