A polysaccharide of Dendrobium officinale ameliorates H2O2-induced apoptosis in H9c2 cardiomyocytes via PI3K/AKT and MAPK pathways

• Published in: International journal of biological macromolecules Vol. 104; no. Pt A; pp. 1 - 10
• Main Authors: Zhang, Jing-yi, Guo, Ying, Si, Jin-ping, Sun, Xiao-bo, Sun, Gui-bo, Liu, Jing-jing
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2017
• Subjects: active ingredients; antioxidant activity; Apoptosis; cardiomyocytes; cardioprotective effect; cardiovascular diseases; Dendrobium officinale; hydrogen peroxide; lipid peroxidation; MAPK; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; Oriental traditional medicine; Oxidative stress; PI3K/Akt; Polysaccharide; polysaccharides; signal transduction; survival rate; Oxidative stress; Dendrobium officinale; MAPK; Polysaccharide; Apoptosis; PI3K/Akt

•In this paper, we isolated and purified a homogeneous polysaccharide with molecular weight of 951.9kDa composed of glucose:galactose:mannose=2.13:1.34:1.00.•D. officinale polysaccharide may protest H9c2 cardiomyocytes apoptosis from H2O2-induced oxidative damage.•D. officinale polysaccharide could...