Primed polymorphonuclear leukocytes from hemodialysis patients enhance monocyte transendothelial migration

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 313; no. 5; pp. H974 - H987
• Main Authors: Kliger, Eynav, Kristal, Batya, Shapiro, Galina, Chezar, Judith, Sela, Shifra
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2017
• Subjects: Accumulation; Antioxidants; Arteriosclerosis; Atherosclerosis; Atherosclerosis - pathology; Biomarkers; Catalase; Catalase - pharmacology; Cell activation; Cell Adhesion - physiology; Chemokine CCL2; Coculture Techniques; Dialysis; Effects; Endothelial cells; Endothelium, Vascular; Granulocytes; Hemodialysis; Human Umbilical Vein Endothelial Cells; Humans; Kidney Failure, Chronic - blood; Leukocyte migration; Leukocytes; Leukocytes (polymorphonuclear); Macrophage Activation; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Monocytes - physiology; Neutrophils - physiology; Patients; Priming; Renal Dialysis; Superoxide dismutase; Superoxide Dismutase - pharmacology; Transendothelial and Transepithelial Migration - physiology; Umbilical vein; Yield; atherosclerosis risk factors; endothelial dysfunction; PMNL priming; monocyte transmigration
• ISSN: 0363-6135; 1522-1539; 1522-1539
• DOI: 10.1152/ajpheart.00122.2017

Increased counts and priming of peripheral polymorphonuclear leukocytes (PMNLs) are associated with future or ongoing atherosclerosis; however, the role of PMNLs in enhancing monocyte transendothelial migration is still unclear. Our aims were to examine endothelial and monocyte activation, transmigr...