Viral use and subversion of membrane organization and trafficking

Membrane trafficking is an essential cellular process conserved across all eukaryotes, which regulates the uptake or release of macromolecules from cells, the composition of cellular membranes and organelle biogenesis. It influences numerous aspects of cellular organisation, dynamics and homeostasis...

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Bibliographic Details
Published inJournal of cell science Vol. 134; no. 5
Main Authors Hernandez-Gonzalez, Miguel, Larocque, Gabrielle, Way, Michael
Format Journal Article
LanguageEnglish
Published England 04.03.2021
Subjects
Biological Transport
Cell Membrane
Humans
Virus Diseases
Virus Replication
Viruses
Infection
Virus
Membrane trafficking
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Summary:Membrane trafficking is an essential cellular process conserved across all eukaryotes, which regulates the uptake or release of macromolecules from cells, the composition of cellular membranes and organelle biogenesis. It influences numerous aspects of cellular organisation, dynamics and homeostasis, including nutrition, signalling and cell architecture. Not surprisingly, malfunction of membrane trafficking is linked to many serious genetic, metabolic and neurological disorders. It is also often hijacked during viral infection, enabling viruses to accomplish many of the main stages of their replication cycle, including entry into and egress from cells. The appropriation of membrane trafficking by viruses has been studied since the birth of cell biology and has helped elucidate how this integral cellular process functions. In this Review, we discuss some of the different strategies viruses use to manipulate and take over the membrane compartments of their hosts to promote their replication, assembly and egress.
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ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.252676