The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

• Published in: Journal of clinical medicine Vol. 7; no. 10; p. 340
• Main Authors: Harris-Love, Michael O., Avila, Nilo A., Adams, Bernadette, Zhou, June, Seamon, Bryant, Ismail, Catheeja, Zaidi, Syed H., Kassner, Courtney A., Liu, Frank, Blackman, Marc R.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 10.10.2018
• Subjects: computed tomography; muscle strength; quantitative ultrasound; muscle quality; echogenicity; aging; metabolic status; muscle tissue composition; myosteatosis; sarcopenia
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm7100340

Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate measure of muscle quality in a sample of older, predominantly African American (AA) participants. We examined the association of rectus femoris echogenicity with mid-thigh computed tomography (CT) scan estimates of intra- and intermuscular adipose tissue (IMAT), basic metabolic parameters via blood sample analysis, muscle strength, and mobility status. This observational study was conducted at a federal medical center and included 30 community-dwelling men (age, 62.5 ± 9.2; AA, n = 24; Caucasian, n = 6). IMAT estimates were significantly associated with echogenicity (r = 0.73, p < 0.001). Echogenicity and IMAT exhibited similar associations with the two-hour postprandial glucose values and high-density lipoproteins values (p < 0.04), as well as grip and isokinetic (180°/s) knee extension strength adjusted for body size (p < 0.03). The significant relationship between ultrasound and CT muscle composition estimates, and their comparative association with key health-related outcomes, suggests that echogenicity should be further considered as a surrogate measure of muscle quality.