Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: Can retrospective data help us?

• Published in: The veterinary journal (1997) Vol. 170; no. 2; pp. 230 - 236
• Main Authors: Smith, M.A., Edwards, G.B., Dallap, B.L., Cripps, P.J., Proudman, C.J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2005
• Subjects: animal pathology; Animals; Cisapride - therapeutic use; Digestive System Surgical Procedures - adverse effects; drug evaluation; drug therapy; Erythromycin - therapeutic use; Evidence based medicine; Gastrointestinal Agents - therapeutic use; Horse Diseases - drug therapy; Horse Diseases - etiology; Horses; Ileus; Ileus - complications; Ileus - drug therapy; Ileus - etiology; Ileus - veterinary; intestinal obstruction; Lidocaine - therapeutic use; lipoma; Metoclopramide - therapeutic use; Pedunculated lipoma; postoperative complications; postoperative ileus; prokinetic drugs; Prokinetics; Retrospective Studies; Risk Factors; statistical analysis; Prokinetics; Pedunculated lipoma; Evidence based medicine; Ileus
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2004.06.006

The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not ( P = 0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited efficacy of prokinetics as treatment for POI. It is postulated that the identified association between hospital and survival reflects differences in clinician decision making. The study highlights the need for further prospective studies using randomised clinical trials to evaluate accurately the efficacy of prokinetic agents. This report illustrates difficulties with performing retrospective analysis of clinical data to determine the efficacy of treatment regimes.