Alkamides from Phyllanthus fraternus

• Published in: Planta medica Vol. 64; no. 2; pp. 192 - 193
• Main Authors: Sittie, A.A, Lemmich, E, Olsen, C.E, Hviid, L, Christensen, S.B
• Format: Journal Article
• Language: English
• Published: Germany 01.03.1998
• Subjects: amides; Amides - chemistry; Amides - isolation & purification; Amides - pharmacology; Animals; antimicrobial properties; antiprotozoal agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - isolation & purification; Antiprotozoal Agents - pharmacology; bioassays; chemical structure; Humans; Leishmania major; Leishmania major - drug effects; Lymphocyte Activation - drug effects; Lymphocytes - drug effects; Lymphocytes - immunology; medicinal plants; Phyllanthus; Plants, Medicinal; Plasmodium falciparum; Plasmodium falciparum - drug effects; structure-activity relationships; Ghana

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial a...