Alkamides from Phyllanthus fraternus

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial a...

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Bibliographic Details
Published inPlanta medica Vol. 64; no. 2; pp. 192 - 193
Main Authors Sittie, A.A, Lemmich, E, Olsen, C.E, Hviid, L, Christensen, S.B
Format Journal Article
LanguageEnglish
Published Germany 01.03.1998
Subjects
amides
Amides - chemistry
Amides - isolation & purification
Amides - pharmacology
Animals
antimicrobial properties
antiprotozoal agents
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
bioassays
chemical structure
Humans
Leishmania major
Leishmania major - drug effects
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Lymphocytes - immunology
medicinal plants
Phyllanthus
Plants, Medicinal
Plasmodium falciparum
Plasmodium falciparum - drug effects
structure-activity relationships
Ghana
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Summary:Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-957405