Meta-Analysis of the Association of the Cathepsin D Ala224Val Gene Polymorphism with the Risk of Alzheimer’s Disease: A HuGE Gene-Disease Association Review

• Published in: American journal of epidemiology Vol. 159; no. 6; pp. 527 - 536
• Main Authors: Ntais, Christos, Polycarpou, Anastasia, Ioannidis, John P. A.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 15.03.2004; Oxford Publishing Limited (England)
• Subjects: Alzheimer disease; Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Alzheimer's disease; Analysis. Health state; Apolipoproteins E - genetics; Biological and medical sciences; cathepsin D; Cathepsin D - genetics; confidence interval; CTSD; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Epidemiology; Gene expression; General aspects; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; genetics; Genotype & phenotype; Health risk assessment; Heterogeneity; Humans; Medical sciences; meta-analysis; Neurology; odds ratio; polymorphism (genetics); Polymorphism, Genetic - genetics; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk; Risk factors; Alzheimer disease; Risk; Review; Epidemiology; Metaanalysis; Association; Gene; Genetics; Aspartic endopeptidases; Degenerative disease; Cathepsin D; polymorphism (genetics); CTSD; Public health; Human; Nervous system diseases; Enzyme; meta-analysis; Cerebral disorder; Peptidases; Central nervous system disease; Risk factor; Hydrolases; Bibliographic review; Polymorphism

A C-to-T polymorphism in exon 2 of the cathepsin D gene encoding cathepsin D (CTSD) has been implicated as a risk factor for Alzheimer’s disease. The authors performed a meta-analysis of 14 studies (16 comparisons) with CTSD genotyping (3,174 Alzheimer’s disease cases and 3,298 controls). Overall, t...