Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application

• Published in: Journal of molecular structure Vol. 1074; pp. 376 - 383
• Main Authors: Singh, Ajay K., Pandey, Sarvesh K., Pandey, O.P., Sengupta, S.K.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.09.2014
• Subjects: Antiinfectives and antibacterials; Antimicrobial activity; Aspergillus niger; Bacillus subtilis; Bacteria; Curvularia; Cyrtomium falcatum; EDX; Fusarium; Microspheres; Nuclear magnetic resonance; Oxadiazoles; Pseudomonas aeruginosa; Salmonella typhi; Scanning electron microscopy; Schiff bases; SEM; Spectra; Streptococcus pyogenes; TGA; Zinc(II); EDX; Schiff bases; Antimicrobial activity; SEM; Zinc(II); TGA
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2014.06.009

•Nano-sized zinc(II) complexes were synthesized and well characterized.•Schiff base and Zn(II) complexes showed significant antimicrobial activities.•Zn(II) complexes look like a microsphere and their sizes are 1–2μm. Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)2(H2O)2] and [Zn(L′)(H2O)2]; LH=Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L′H2=Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300°C.