Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges

This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. On-chip and microfluidics combined devices along with optical microresonator...

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Bibliographic Details
Published inLab on a chip Vol. 16; no. 14; pp. 2572 - 2595
Main Authors Toren, Pelin, Ozgur, Erol, Bayindir, Mehmet
Format Journal Article
LanguageEnglish
Published England 05.07.2016
Subjects
Biomarkers
Deoxyribonucleic acid
Focusing
Multiplexing
Oligonucleotides
Ribonucleic acids
Robustness
Strategy
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Summary:This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. On-chip and microfluidics combined devices along with optical microresonators provide rapid, robust, reproducible and multiplexed biodetection abilities in considerably small volumes. We present a detailed overview of the studies conducted so far, including biodetection of various oligonucleotide biomarkers as well as deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs) and proteins. We particularly advert to chemical surface modifications for specific and selective biosensing. This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems.
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ISSN:1473-0197
1473-0189
DOI:10.1039/c6lc00521g