Chemoprophylactic studies with ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata

Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0.2 mg/kg monthly and two others given 0.3 mg/kg monthly as well as three control animals became patent for microfilaraemia....

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Bibliographic Details
Published inJournal of helminthology Vol. 61; no. 4; p. 311
Main Authors Mak, J W, Lam, P L, Rain, A N, Suresh, K
Format Journal Article
LanguageEnglish
Published England 01.12.1987
Subjects
Animals
Brugia
Cercopithecidae
Elephantiasis, Filarial - prevention & control
Female
Filariasis - prevention & control
Ivermectin - therapeutic use
Male
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Summary:Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0.2 mg/kg monthly and two others given 0.3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8.2% and 6.2% in the lower dosage and control groups respectively.
ISSN:0022-149X
DOI:10.1017/S0022149X00010221